Method and compositions of treating Parkinsonisms with levodopa

Details Method and compositions of treating Parkinsonisms with levodopa Method and compositions of treating Parkinsonisms with levodopa

1978-09-01

1980-02-26

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424331, A61K 3112, A61K 31195

Patent

active

041906721

ABSTRACT:
Improved methods are provided for the treatment of the central nervous system dopamine-deficiency diseases (CNS-DADD's), including Parkinson's disease and other parkinsonisms, which comprises the administration of 3',4'-dihydroxy-2-methyl-isopropiophenone (DHMPP) in an amount effective to inhibit the conversion of levodopa to 3-O-methyldopa (OMD) by catechol-O-methyl transferase (COMT). The present method results in a reduction of the dosage of levodopa otherwise required to symptomatically control the CNS-DADD, providing a concomitant reduction in the untoward side effects of levodopa administration. Also provided are novel pharmaceutical compositions of levodopa and DHMPP.

REFERENCES:
patent: 2929848 (1960-03-01), Woodruff et al.
patent: 3790674 (1974-02-01), Rodriguez
patent: 3984545 (1976-10-01), Fril, Jr. et al.
patent: 3991207 (1976-11-01), Sarges et al.
Chem. Abst., vol. 67-8134a (1967).

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