Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-

Details Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3- Pharmaceutical preparation and use of 4-hydroxy-2-quinolinone-3-

1977-06-20

1980-02-26

Wheeler, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546155, A61K 3147

Patent

active

041906594

ABSTRACT:
Disclosed are compounds which are 4-hydroxy-2-quinolinone-3-carboxylic acid esters, e.g., 1-methyl-4-hydroxy-2-quinolinone-3-carboxylic acid ethyl ester, useful as anti-allergic agents and intermediates for 1-alkyl-4-alkoxy-quinolin-2(1H)-ones, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic ester.

REFERENCES:
patent: 3657223 (1972-04-01), Hellerbach et al.
patent: 3772301 (1973-11-01), Strandtmann
patent: 3772305 (1973-11-01), Hellerbach et al.
patent: 4107310 (1978-08-01), Allais etal.
patent: 4119720 (1978-10-01), Hardtmann
McCorkindale, Tetrahedron, 1961, vol. 14, pp. 223-229.
Coutts et al., Chem. Abst., 1962, vol. 57, p. 5891(e).
Brown, Ibid, 1955, vol. 50, p. 1010(c).
Burger, Medicinal Chemistry, 1963, p. 42 (Interscience Pub. Co.).
Asahina et al., Berich. Deutchen Chem. Gessellschaft, vol. 63, 1930, pp.2052ff.
Grundon et al., Source not available, (1955), pp. 4284-4290.
Brown, "Australian J. Chem.", (1954), vol. 8, pp. 348-377.

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