Process for the manufacture of p-hydroxyphenyl-acetic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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C07C 6501

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active

045902950

ABSTRACT:
p-Hydroxyphenylacetic acid is prepared by reduction of p-hydroxymandelic acid with HI in the presence of red phosphorus. According to a preferred embodiment, the reaction is carried out in one vessel in which the mandelic acid is prepared in situ from phenol and glyoxylic acid.

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