Preparing indoline derivatives

Details Preparing indoline derivatives Preparing indoline derivatives

1985-03-15

1986-05-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07C20912

Patent

active

045902801

ABSTRACT:
An improved process for preparing sulfonylated indoline compounds of the formula ##STR1## via reduction of a nitrodiol of the formula ##STR2## where R.sub.1 and R.sub.3 are defined in the specification, to obtain the corresponding aminodiol ##STR3## and then the aminodiol (III) is sulfonylated and cyclized in situ to obtain the sulfonylated indoline compound (I). The substituted indoline compounds (I) are useful in overall processes for making 1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4(5H)-ones which have useful light absorber, anti-bacterial and anti-tumor pharmaceutical use properties.

REFERENCES:
patent: 4169888 (1979-10-01), Hanka et al.
patent: 4424365 (1984-01-01), Wierenga
D. G. Martin, C. G. Chidester, D. J. Duchamp and S. A. Mizsak, J. Antibiot., 33, 902 (1980), "Structure Proof of Antibiotic CC-1065".

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