Human IgG.sub.1 monoclonal antibody specific for the nicotinic a

Details Human IgG.sub.1 monoclonal antibody specific for the nicotinic a Human IgG.sub.1 monoclonal antibody specific for the nicotinic a

1988-03-30

1993-03-09

Lacey, David L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

53038815, 53038822, 4351722, 435 7021, C12N 524, C12N 1502, C07K 1528, C12P 2108

Patent

active

051926849

ABSTRACT:
A human IgG.sub.1 type monoclonal antibody which possesses a molecular weight in the range of 180,000.+-.20,000 as measured by the method of polyacrylamide gel electrophoresis performed in the presence of sodium dodecyl sulfate and is specific to nicotinic acetylcholine receptor. The human IgG.sub.1 type monoclonal antibody mentioned above is produced by a method which comprises fusing human cells capable of producing an antibody against nicotinic acetylcholine receptor with propagable human cells thereby giving rise to a hybridoma capable of producing the aforementioned human IgG.sub.1 type monoclonal antibody, selecting the hybridoma from the production of the fusion, culturing the hybridoma thereby giving rise to the aforementioned human IgG.sub.1 type monoclonal antibody, and selecting the antibody from the cultured medium. The hybridoma mentioned above is also identified.

REFERENCES:
Kamo et al., Science 215: 995 1982.
Mittag et al., New England Journal of Medicine 294: 691 1976.
Tzartos et al., PNAS USA 77: 755, 1980.
Buck et al., pp. 275-309 in: Kennett et al. Eds. "Monoclonal Antibodies and Functional Cell Lines" Plenum Press 1984.
Chemical Abstract No. CA105(21): 189033p, Blair et al., Immunol. Invest. 15(4) 351-64 1986.

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