4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl -2-aminoalkyloxymethyl-1

Details 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl -2-aminoalkyloxymethyl-1 4-aryl-3,5-bis(alkoxycarbonyl)-6-methyl -2-aminoalkyloxymethyl-1

1984-03-05

1986-05-20

Lesmes, George F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544364, 544124, 544310, 544336, 546255, 546153, 546193, 546256, 546261, 546262, 546270, 546271, 546274, 546278, 546280, 546282, 546283, 546340, 546341, 514256, 514314, 514318, 514332, 514333, 514335, 514336, 514338, 514339, 514341, 514342, 514343, 514356, C07D40112, C07D21182, C07D21355, A61K 31495, A61K 3144

Patent

active

045901953

ABSTRACT:
1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; n is 2, 3 or 4; R.sup.3 is H, C.sub.1 -C.sub.4 alkyl, CH.sub.2 CO.sub.2 (C.sub.1 -C.sub.4 alkyl) or CH.sub.2 CN; and R.sup.4 is a group of the formula COR.sup.5, CSR.sup.5, C(.dbd.NR.sup.6)R.sup.7 or SO.sub.2 R.sup.5, wherein R.sup.5 is C.sub.1 -C.sub.4 alkyl, NH.sub.2, NH(C.sub.1 -C.sub.4 alkyl), NH(C.sub.3 -C.sub.6 cycloalkyl), N(C.sub.1 -C.sub.4 alkyl).sub.2, NHCH.sub.2 CO.sub.2 (C.sub.1 -C.sub.4 alkyl), NHCH.sub.2 CONH.sub.2, NHCH.sub.2 CO.sub.2 H, NH(CH.sub.2).sub.2 NH.sub.2, NHNH.sub.2, NHNRCO.sub.2 (C.sub.1 -C.sub.4 alkyl), NH-aryl, NHCO-aryl or a heterocyclic, NH-heterocyclic or NHCO-heterocyclic group, or when R.sup.4 is C(.dbd.O)R.sup.5, R.sup.5 may be H or CF.sub.3 ; R.sup.6 is H, CN, CO.sub.2 (C.sub.1 -C.sub.4 alkyl), CO(C.sub.1 -C.sub.4 alkyl), SO.sub.2 (C.sub.1 -C.sub.4 alkyl), SO.sub.2 -aryl, SO.sub.2 NH.sub.2, SO.sub.2 N(C.sub.1 -C.sub.4 alkyl).sub.2, NO.sub.2 or aryl; and R.sup.7 is NH.sub.2, NH(C.sub.1 -C.sub.4 alkyl), NHCO(C.sub.1 -C.sub.4 alkyl), NH(CH.sub.2).sub.m N(C.sub.1 -C.sub.4 alkyl).sub.2 wherein m is 2 to 4 or a NH-heterocyclic group; and their pharmaceutically acceptable acid addition salts, and pharmaceutical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

REFERENCES:
patent: 3974278 (1976-08-01), Bossert et al.
patent: 4380547 (1983-04-01), Materne
patent: 4430333 (1984-02-01), Campbell et al.

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