Phospholipase A.sub.2 inhibition using 4,1-benzoxazepine-2-(3H)-

Details Phospholipase A.sub.2 inhibition using 4,1-benzoxazepine-2-(3H)- Phospholipase A.sub.2 inhibition using 4,1-benzoxazepine-2-(3H)-

1984-12-19

1986-05-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393B, A61K 3155, C07D26714

Patent

active

045901872

ABSTRACT:
The present invention provides certain novel 4,1-benzoxazepin-2(3H)-ones which are useful as inhibitors of phospholipase A.sub.2 and thus as inhibitors of arachidonate mobilization. These compounds are thus useful whenever it is medically necessary or desirable to inhibit the biosynthesis of the products of the arachidonic acid cascade.

REFERENCES:
patent: 3122554 (1984-02-01), Poos
patent: 3346565 (1967-10-01), Testa et al.
patent: 3598808 (1971-08-01), Szmuszkovicz
patent: 4297280 (1981-10-01), Hirai et al.
patent: 4307091 (1981-12-01), Brown et al.
patent: 4341704 (1982-07-01), Hirai et al.
Chemical Abstracts, vol. 63, cols. 18088-18089 (1965), abstracting Testa et al. in "Farmaco" (Pavia) (Ed. Sci.), vol. 20, No. 5, pp. 323-335 (1965).
Derwent Farmdoc 27355E and 25429C.

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