Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai
Patent
1985-04-22
1986-05-20
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ortho-hydroxybenzoic acid or derivative doai
A61K 3161
Patent
active
045901830
ABSTRACT:
The method of providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises orally administering either prior to or in combination with aspirin a cytoprotectively effective amount of sodium thiosulfate alone or in combination with a pharmaceutically acceptable carrier. Also shown is a composition for providing cytoprotection of the gastric mucosa in a mammal receiving aspirin perorally which comprises aspirin in combination with a cytoprotectively effective amount of sodium thiosulfate.
REFERENCES:
patent: 3988466 (1977-10-01), Takagi et al.
patent: 4016268 (1977-04-01), Goldenberg et al.
patent: 4491574 (1985-01-01), Seifter et al.
Sodium Thiosulfate, The Merck Index, Eighth Edition, 1968, pp. 967-968.
Sodium Thiosulfate, The Merck Index, Tenth Edition, 1983, item 8542 (p. 1243).
Fasth et al., Biochemical Pharmacology, 22, 1337-1351 (1973), entitled "Protective Effect of Thiosulfate and Metabolic Thiosulfate Precursors Against Toxicity of Nitrogen Mustard (HN.sub.2)".
Bair Robert K.
DuPont Paul E.
Friedman Stanley J.
Sterling Drug Inc.
Wyatt B. Woodrow
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