Process for the preparation of 3-(2'-fluorophenyl)pyridine

Details Process for the preparation of 3-(2'-fluorophenyl)pyridine Process for the preparation of 3-(2'-fluorophenyl)pyridine

1986-09-15

1989-01-10

Warden, Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546296, 546297, 546303, 546304, 546307, 546311, 546339, 546344, 546345, 546346, C07D21326

Patent

active

047974907

ABSTRACT:
6-Fluoro-7-pyridylquinolone carboxylic esters and acids having antibacterial activity are prepared by coupling of a 2-fluorophenyl-metallic compound with a pyridyl bromide or iodide in the presence of a transition metal catalyst, nitrating and hydrogenating the pyridyl-2-fluorophenyl compound formed, introducing a substituent on the nitrogen of the amine formed, and cyclizing after reacting with a dialkyl or dibenzyl ethoxymethylene malonate to form a 6-fluoro-7-pyridyl-1,4-dihydroquinol-4-one 3-carboxylate, and hydrolyzing to the corresponding acid.

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