Bis-amidines

Details Bis-amidines Bis-amidines

1985-10-15

1986-05-20

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

548422, 2602457, 544 585, 544142, 546199, 514222, 514234, 514410, A61K 3140, C07D40304

Patent

active

045900744

ABSTRACT:
Symmetrical bis-amidine derivatives of mitomycin C may be converted to unsymmetrical bis-amidine analogs by reaction with secondary amines. The compounds are active anti-tumor agents in experimental animal tumors.

REFERENCES:
patent: 3660578 (1972-05-01), Tojuhata et al.
Matsui et al., J. Antibiotics, vol. XXI (1968) pp. 189-198.

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