Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors

Details Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors Diaryl-5-oxygenated-2-(5H) -furanones as COX-2 inhibitors

1995-05-18

1997-11-25

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548204, 548206, 548236, 548333, 548405, 549313, 549318, A61K 31365, C07D30760

Patent

active

056913745

ABSTRACT:
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

REFERENCES:
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patent: 4427693 (1984-01-01), Haber
patent: 5207817 (1993-05-01), Kramer et al.
patent: 5344991 (1994-09-01), Reitz et al.
patent: 5393790 (1995-02-01), Reitz et al.
Dikshit, et al., Indian Journal of Chem., vol. 29B, pp. 954-960 (1990).
Lombardino, et al., Arzneim-Forsch. (Drug Res.), vol. 25, NR. 10, pp. 1629-1635 (1975).
Yang, et al., J. Chem. Soc., Chem. Commun., pp. 656-658 (1992).

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