Orally administerable sustained release pharmaceutical formulati

Details Orally administerable sustained release pharmaceutical formulati Orally administerable sustained release pharmaceutical formulati

1985-11-12

1989-01-10

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, A61K 964

Patent

active

047972866

ABSTRACT:
This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.

REFERENCES:
patent: 4625535 (1986-12-01), Angerbauer et al.
Chemical Abstracts, vol. 89: 80177p "Effect of Hydrophilization of Hydrophobic on Release Rate from Capsules" Leck, C. F. et al J. Pharm. Sci. 1978, 67(7), 935-9.
Chemical Abstracts vol. 91, 1979: 27262c, "In vitro and In Viro Availability of Hydrophilized Phenytoin from Capsules", Lerk, C. F. et al., J. Pharm. Soi. 1979, 68(5), 634-8.
Hunter et al., Pharm. Ind. 45, 4, 433-434 (1983).
Product Bulletin, "The Hard Capsule with the Soft Centre", Elanco Products.
Product Bulletin, "Gelucire.RTM., Gattefosse Corporation (1983).
Francois et al., Pharm. Ind., 44, 1, 86-89 (1982).
Hunter et al., Pharm. Ind., 44, 1, 90-91 (1982).

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