Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1994-11-14
1997-11-25
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435238, 424 9373, 514297, A01N 102, A01N 6300, A01N 4342, C12N 706
Patent
active
056911327
ABSTRACT:
Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes. In particular, quinacrine mustard is used to inactivate pathogens in red cell compositions with retention of red cell function.
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LoGrippo GA et al, Proceedings of the Sixth Congress Int. Soc. Blood Trausfusion, Int. J. of Haematology FASC. 7:225-30 (1958).
Mattes et al, Carcinogenesis 9(11):2065-72 (1988).
Cook David
Nerio Aileen
Wollowitz Susan
Carroll Peter G.
Cerus Corporation
Saucier Sandra E.
Wilke Kathryn P.
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