Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1994-11-22
1997-11-25
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424445, 424448, A61F 1300
Patent
active
056909551
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/GB93/01350, filed Jun. 28, 1993.
The present invention relates to a medicament-impregnated alginate fibre. More particularly, the invention concerns a fibre from which medicament can be released in a controlled manner, and to the application of this fibre in the preparation of alginate fabrics and wound dressings.
A number of methods for producing conventional alginate fibres are described in the art. The extrusion of alginate solutions into an aqueous solution containing calcium ions to form yarns of calcium alginate filaments is known, for example, from British Patents Nos. 567641, 568177, 571657 and 624987. Such fabrics were generally prepared by knitting a yarn of calcium alginate filaments and partially converting the calcium alginate to the sodium form to form a calcium/sodium alginate containing, for example, 30-70 percent by weight of the carboxyl groups of the alginate in the calcium form.
U.S. Pat. No. 4,421,583 discloses a process for making a non-woven alginate fabric useful as a wound dressing which comprises spreading a tow of calcium alginate filaments in a flow of water; overfeeding the spread filaments onto a water-previous support so that the filaments cross over each other; and drying the filaments so that the filaments become bonded to each other at their points of contact where they cross over each other. Non-woven alginate fabrics having this high calcium content of 70 to 95 percent are said to be useful for example as throat swabs, which after swabbing are dissolved in sodium hexametaphosphate solution. The non-woven alginate fabrics can be treated such that calcium is partially replaced by sodium, for example by treatment with alcoholic sodium hydroxide and sodium acetate so that from 30 to 70 percent of the carboxyl groups are in the sodium form. The sodium calcium alginate fabrics produced are said to be useful as haemostatic wound dressings which can be absorbed by body fluids, for use for example in deep surgery or after tooth extraction.
WO-A-84/03705 describes a method of producing alginate fibres for fabric of increased solubility in water or saline solutions for application in the medical field and in particular for haemostatic dressings.
U.S. Pat. No. 4,562,110 describes a method of producing dried alginate fibre material which comprises spinning an alginate solution into an aqueous salt bath. The wet-spun continuous fibres of insoluble alginate, in which the fibres are separate but generally parallel, are collected, and the sheet of fibres is laid on a moving conveyor belt which is travelling at a slower speed than the sheet fibre feed speed, so that the fibres become overlaid in a web of defined width. The fibre web is dried and stretched in a manner to reduce the bonding between the fibres. The web is said to be useful as a component of medicated and surgical dressings.
Wound dressings which may incorporate certain medicaments are also known in the art. For example, EP-A-0279118 describes an adhesive product suitable for use on wounds comprising a backing layer of a moisture vapour transmitting continuous polymer film and a layer of a pressure sensitive adhesive containing inter alia at least 30% by weight of alginate. The adhesive product described therein can contain a medicament, such as a chlorhexidine derivative, normally in the adhesive layer. Alternatively, the medicament may form part of the alginate polymer used for the pressure sensitive adhesive layer, suitable examples being stated to include silver, copper and zinc derivatives of sodium alginate.
Additionally, U.S. Pat. No. 4,753,231 discloses the incorporation of such antibacterial agents as silver sulphadiazine, povidone-iodine, chlorhexidine salts such as gluconate, acetate and hydrochloride, and quaternary agents such as benzalkonium chloride into a wound dressing pad.
Moreover, U.S. Pat. No. 4,817,594 discloses wound dressings as supports for therapeutic or antiseptic materials including iodine, formol, lime, oxygen, bacillary toxins and the like.
The commercially availa
Griffiths Bryan
Mahoney Pter Michael John
E. R. Squibb & Sons Inc.
Furman Jr. Theodore R.
Kilcoyne John M.
Phelan D. Gabrielle
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