Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-06
2000-09-26
Duffy, Patricia A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 5303891, C07K 1600
Patent
active
061244384
ABSTRACT:
Antibodies or epitope-binding portions thereof raised to a synthetic polypeptide having an amino acid sequence that corresponds substantially to an amino acid residue sequence of at least a portion of a naturally occurring proteinoid and having a molecular weight equal to less than that of the proteinoid are diclosed. That proteinoid contains an amino acid residue sequence translated from a messenger RNA present substantially only in brain cells. Those antibodies or epitope-containing portions bind specifically when admixed with brain cell tissue that includes the naturally occurring proteinoid.
REFERENCES:
patent: 3949064 (1976-04-01), Bornstein et al.
patent: 4205057 (1980-05-01), Whitaker
patent: 4237224 (1980-12-01), Cohen et al.
patent: 4312857 (1982-01-01), Coy et al.
patent: 4342832 (1982-08-01), Goeddel et al.
patent: 4350627 (1982-09-01), de Castiglione et al.
patent: 4350764 (1982-09-01), Baxter et al.
patent: 4388236 (1983-06-01), Stein
patent: 4389342 (1983-06-01), Reinhard
patent: 4401759 (1983-08-01), Rubin et al.
patent: 4415558 (1983-11-01), Vale, Jr. et al.
patent: 4416988 (1983-11-01), Rubin
patent: 4425269 (1984-01-01), Christy et al.
patent: 4430428 (1984-02-01), Fraser et al.
patent: 4457917 (1984-07-01), Schaller
patent: 4462941 (1984-07-01), Lee et al.
patent: 4469631 (1984-09-01), Baxter et al.
patent: 4481191 (1984-11-01), Wei et al.
patent: 4677195 (1987-06-01), Hewick et al.
patent: 4900811 (1990-02-01), Sutcliffe
patent: 5030565 (1991-07-01), Niman et al.
patent: 5242798 (1993-09-01), Sutcliffe
Dahl et al, Brain Research, 57:343-360, 1973.
Hycen, et al, Journal of Neurobiology, 9(6):489-492, 1978.
Lakin et al, Journal of Neurochemistry, 37(5):1170-1178, 1981.
Izant et al, Proc. Natl. Acad. Sci., 77(8):4741-4745, Aug. 1980.
Haan et al, Proc. Natl. Acad. Sci., 79:7585-7589, Dec. 1982.
Sutcliffe et al, Cell 33:671-682, July 1983.
Lai et al, Proc. Natl. Acad. Sci, 84:4337-4341, 1987.
Rueger et al, Analytical Biochemistry, 89:360-371, 1978.
Sato et al, Biochemical and Biophysical Research Communications, 163(3):1473-1481, Sep. 29, 1989.
Langley et al., Journal of Neurocytology, vol. 9, No. 6:783-798, 1980.
Poletaev et al, Bulletin of Experimental Biology and Medicine 83(2):152-154, 1977.
Ignator, S.A., ZH, Nervopat. Psikhiat, Korsakor 77(1):48-51, 1977.
Beck et al, Brain Research, 112:329-335, 1976.
Itoyama et al., Ann. Neurol, 7:167-177, 1980.
Sutcliffe et al, Cold Spring Harbor Symposium on Quantitative Biology. vol. 48. Molecular Neurobiology Conference Date Jun. 1, 1983, Pub date 1983, pp 477-484.
Hawkes et al Cell, 28:253-258, Feb. 1982.
Edelman, GM., Science, 219:450-457, Feb. 4, 1983.
Gheuens et al, Neuroscience Letters, Supplement 10 (1982):5205.
Ostermann et al, Cell Tissue Res 228:459-473, Feb. 2, 1983.
Chem. Abstr., 81:625 (1974).
Chem. Abstr., 100:29938 (1984).
Chem. Abstr., 101:144699 (1984).
Chem. Abstr., 101:85984 (1984).
Chem. Abstr., 103:158508 (1985).
Chem. Abstr., 102:22043 (1985).
Ruggiero et al. Submicrosc. Cytol, 16(1):131-134 (1984).
Valdivia et al., Biochem. biophys. Res. Commun., 105(4):1241-1249 (Apr. 29, 1982).
Lakin et al., J. Neurochem., 41:385-394 (1983).
Flanagan et al., J. Neurochem, 46(2):542-544 (1986).
Ripellino et al., J. Neurochem., 53:1103-1108 (1989).
Green et al., Cell, 28:477-478 (Mar. 1982).
Sutcliffe et al., Science, 219:660-666 (1983).
Sutcliffe et al., Cell, 33:671-682 (1983).
Milner et al., Nucleic Acids Res., 11(6):5497-5520 (1983).
Guillemin, Science, 202:390-402 (1978).
Bantle et al., Cell, 8:139-150 (1976).
Hastie et al., Cell, 9:761-774 (1976).
Sutcliffe et al., Proc. Nat'l. Acad Sci. U.S.A., 79:4942-4946 (1982).
Southern, J. Mol. Biol., 98:503-517 (1975).
Gros et al., Molecular Genetic Neuroscience, Schmidt, Bird and Bloom, eds., Raven Press, New York 335-347 (1982).
Cleveland et al., Cell, 20:95-105 (1980).
Green et al., Cell, 28:477-487 (1979).
Naranishi et al., Nature, 278:423-427 (1979).
Amara et al., Nature, 298:240-244 (1982).
Land et al., Nature, 295:299-303 (1982).
Kakidani et al., Nature, 298:245-249 (1982).
Towbin et al., PRoc. Natl. Acad. Sci. USA, 76:4350-4354 (1979).
Elder et al., Proc. Natl. Acad. Sci. USA, 79:4540-4544 (1982).
French et al., Regulatory Peptides, 1:127-146 (1980).
Koob et al., Regulatory Peptides, 2:153-163 (1981).
Barnstable, Nature: 286:231-235 (1982).
Thomas, Proc. Natl. Acad. Sci. USA, 77:5201-5205 (1980).
Rigby et al. J. Mol. Biol., 113:237-251 (1977).
Laemmli, Nature, 227:680-682 (1971).
Tanaka et al., J. Bacteriol., 121:354-362 (1975).
Sutcliffe, Nucleic Acid Res., 5:2721-2728 (1978).
Maxam et al., Proc. Natl. Acad. Sci. USA, 74:560-564 (1977).
Bittle et al., Nature, 298:30-33 (1982).
Bloom et al., Proc. Natl. Acad. Sci. USA, 75:1591-1595 (1978).
Schibler et al., J. Mol. Biol., 142:93-116 (1980).
Aviv et al., Proc. Natl. Acad. Sci. USA, 69:1408-1412 (1972).
Wickens et al., J. Biol. Chem., 253:2483-2495 (1978).
Gough et al., Biochemistry, 19:2702-2710 (1980).
Jacobsen et al., Eur. J. Biochem., 45:623-627 (1974).
Roychoudary et al., Nucleic Acids Res., 3:865-877 (1976).
Birnboim et al., Nucleic Acids Res., 7:1513 (1979).
Rave et al., Nucleic Acid Res., 6:3559-3567 (1979).
Denhardt, Bichem. Biophys. Res. Comm.m 23:641-646 (1966).
Melli et al., J. Mol. Biol., 93:23-38 (1975).
Dermen et al., Cell, 23:731-739 (1981).
Rivier, J. Chromatogr., 202:211-222 (1980).
Arnheiter et al., Nature, 294:278-280 (1981.
Bodor, Science, 214:1380-1372 (1981).
Tachibana et al., Nature, 295:339-340 (1982).
Goedert et al., Develop. Brain Res., 200:127-131 (1985).
Rivier et al., Fed. Proc., 44:189-195 (1985).
Herbert, Trends in Biochemical Science, 6:184-188 (1981).
O'Sullivan, C & EN, pp. 26-27 (Nov. 15, 1976).
Numa et al., Trends in Biochemical Science, 6:274-277, (1981).
Noda et al., Nature, 297:431-434 (1982).
Comb et al., Nature, 295:663-666 (1982).
Gubler et al., Nature, 295:206-208 (1982).
Rossler et al., Nature, 298: 221-222 (1982).
Marx, Science, 220:395-397 (1983).
Meisenberg et al., Life Sciences, 32:2611-2623 (1983).
Goldstein, Science, 193:1081-1086 (1976).
Brilliant et al., Mol. Cell Biol., 4:2187 (1984).
Kreiner et al., J. Neurosci., 4:2581 (1981).
Schmidt, Neuroscience, 13:991 (1984).
Petrusz et al., Fed. Proc., 44:299 (1985).
W. Broad and N. Wade, Betrayers of the Truth, Simon and Schuster, New York (1982) p. 54.
Cole et al., Science, 178:368-375 (1972).
Hidaka et al., J. Biol. Chem., 258:2705-2709 (1983).
Duffy Patricia A.
The Scripps Research Institute
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