Polymers containing prostaglandin radicals, process for their pr

Drug – bio-affecting and body treating compositions – Lymphokine

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424 19, 424 78, 525329, 525379, 525380, 525382, 525384, A61K 3178

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active

042281520

ABSTRACT:
There are disclosed non-toxic polymers having a molecular weight between 1,000 and 1,500,000 and containing prostaglandin radicals directly connected or connected through an oxyalkylenic, aminoalkylenic, or oxyaminoalkylenic chain to a polyacrylic or polymethacrylic backbone. Upon entry of the polymer into the body, the prostaglandin radicals are hydrolyzed causing free prostaglandins to be released in the body. Methods for making the non-toxic polymers and therapeutic compositions containing the non-toxic polymers are also disclosed.

REFERENCES:
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patent: 3764477 (1973-10-01), Lehmann et al.
patent: 3811444 (1974-05-01), Heller et al.
patent: 3898986 (1975-08-01), Zaffaroni
patent: 3932656 (1976-01-01), Ramwell et al.
patent: 4062855 (1977-12-01), Graham et al.
patent: 4145320 (1979-03-01), Ferruti et al.
Ferruti et al., Polymer, vol. 13, pp. 462-464 (Oct. 1972).
Ferruti, Researches on Polymers, Dorprecht (Holland, Dec. 1973), pp. 73-101.
Ferruti et al., J. of Polymer Science, Polymer Chem. Ed., vol. 12, pp. 553-559 (1974).

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