Certain triazole compounds and their pharmaceutical uses

Details Certain triazole compounds and their pharmaceutical uses Certain triazole compounds and their pharmaceutical uses

1993-08-26

1996-03-12

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548247, 5482644, C07D40104, C07D40304

Patent

active

054987202

ABSTRACT:
In the invention of novel nonsteroidal antiinflammatory compounds the title novel triazole compounds, were synthesized from carboxylic acids, 2,5-acetonylacetone, or isoniazid, respectively. To give 4H-1,2,4-triazol-3-thiols. Treatment of 4H-1,2,4-tri-azol-3-thiols with methyl chloroacetate or methyl .alpha.-chloropropionate resulted in the formation of compounds I-VI. The antiinflammatory activity of those new triazole compounds were determined by the carrageenin-induced edema method and they showed potent activity. In the dosage form studies those compounds of formula I-VI were added suituble vehicleo to prepare antiinflammatory agents.

REFERENCES:
Sung et al., Journal of Heterocyclic Chemistry, vol. 29, No. 5, pp.-1101-1109 (Aug.-Sep. 1992).

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