Metalloproteinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142382, 5142378, 514311, 514331, 514332, 514341, 514365, 514396, 514361, 514406, 514432, 514445, 514451, 514507, 514541, 514602, 514357, 514604, 544 581, 544168, 544169, 544130, 544131, 544133, 540524, 540531, 546175, 546194, 546247, 546209, 546265, 5462834, 5462821, 546333, 546337, 5462804, 5462844, 5462817, 5462751, 548127, 548185, 548205, 5483351, 5483381, 549 13, 549 65, 549426, 564 84, 564 90, 564 92, 564 94, 560 13, 560312, A61K 31426, C07D27726

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active

061243337

ABSTRACT:
Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.

REFERENCES:
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G. R. Clemo et al., "The constitution of psi-santonin", J. Chem. Soc., 1946, pp 30-36.
K. Kondo et al., "N-Arylglycine chemotherapeutics. IV. Syntheses of (p-methoxyphenylamino)acetohydroxamic acid, (p-methoxyphenylamino)acetamide, and their derivatives", Chem. Abst., vol. 59, No. 4, Aug. 19, 1963.
N. Yoneda et al., "Reaction of L-alpha-tosylamido-beta-propiolactone. I. Synthesis, reactions with amines and derivation to L-serine", Chem. Abst., vol. 70, No. 19, May 12, 1969.

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