Methods and compositions for stimulating neurite growth

Details Methods and compositions for stimulating neurite growth Methods and compositions for stimulating neurite growth

1997-02-28

2000-09-26

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514357, 514360, 514365, 514374, 514385, 514192, A61K 3144, A61K 3141, A61K 31415, A61K 3143

Patent

active

061243280

ABSTRACT:
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neutering in nerve cells. The compositions comprise a neurotrophic amount of a compound which binds to the FK-506 binding protein (FKBP) and a neurotrophic factor, such as nerve growth factor NGF. The methods comprise treating nerve cells with the above-described compositions or compositions comprising the FKBP binding compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

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patent: 5614547 (1997-03-01), Hamilton et al.
patent: 5696135 (1997-12-01), Steiner et al.
J.P. Steiner et al., "High brain densities of the immunophilin FKBP colocalized with calcinerurin," Nature, 358, pp. 584-587 (1992).
J.R. Hauske et al., "Design and synthesis of novel FKBP inhibitors," J. Med. Chem., 35, pp. 4284-4296 (1992).
B.G. Gold et al., "FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve," Soc. Neurosci. Abs., 19, p. 1316 (1993).
B.G. Gold et al., "The immunosuppressant FK506 increases the Rate of Axonal Regeneration in Rat Sciatic Nerve," J. Neuroscience., 15(11), pp. 7509-7516 (Nov., 1995).
W.E. Lyons et al., "Immunosupressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia," Proc. Natl. Acad. Sci. USA, 91, pp. 3191-3195 (Apr., 1994).
John Sharkey et al., "Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia." Nature, 371, pp. 336-339 (Sep. 22, 1994).
W.E. Lyons et al., "Neuronal regeneration enhances the expression of the immunophilin FKBP-12," J. Neuroscience., 15, pp. 2985-2994 (Apr., 1995).

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