Use of flupirtine for the prophylaxis and therapy of disorders w

Details Use of flupirtine for the prophylaxis and therapy of disorders w Use of flupirtine for the prophylaxis and therapy of disorders w

1997-06-11

2000-09-26

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

061243264

ABSTRACT:
The invention relates to the use of flupirtine or its salts for the production of a medicament for the prophylaxis and therapy of disorders which accompany an unphysiologically high cell death rate. Of particular importance here is the treatment of organ disorders with cell-destroying processes, such as myocardial infarct, shock kidney, shock lung, senile macular degeneration or traumas as a result of mechanical, thermal, radiation or toxic influences.

REFERENCES:
patent: 4481205 (1984-11-01), von Bebenburg et al.
patent: 5336689 (1994-08-01), Weber et al.
patent: 5462965 (1995-10-01), Roba et al.
patent: 5721258 (1998-02-01), Schwarz et al.
Medline abstract AN 95220493, Perovic, S. et al., European Journal of Pharmacology, 288(1), pp. 27-33, Dec. 15, 1994.
Zimmer et al., British Journal of Pharmacology 123: 1154-1158, 1998.
Evans, Ophthalmology, New York: Oxford Univ. Press, pp. 55-78, 1995.
Shandra et al., "Experimental Brain Trauma: Effects of Vitamin Treatment", Journal of Neurotrauma, Jun. 1995, vol. 12, No. 3, PB200, p. 489, XP002043183.
Osborne et al., "Protection of Rabbit Retina From Ischemic Injury by Flupirtine", Investigative Ophthalmology & Visual Science, Feb. 1996, vol. 37, No. 2, pp. 274-280, XP002043185.
S. Perovic et al., "Flupirtine Increases the Levels of Glutathione and Bcl-2 in hNT (human Ntera/D1) Neurons: Mode of Action of the Drug-mediated Anti-apoptotic Effect", European Journal of Pharmacology, vol. 317, No. 1, Dec. 1996, pp. 157-164, XP000673257.
Powell-Jackson et al., "Use of *Flupirtine Maleate as an Analgesic in Patients with Liver Disease", The British Journal of Clinical Practice, Feb. 1985, vol. 39, No. 2, pp. 63-66, XP 002043186.

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