Multidrug resistance modifying dithianes

Details Multidrug resistance modifying dithianes Multidrug resistance modifying dithianes

1992-07-15

1994-04-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33908

Patent

active

053027272

ABSTRACT:
Compounds of the formula ##STR1## wherein R is a residue of the formula ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X, Y and Z are as described, with the exception of rac-N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)-.beta.,N-dimethyl-m -dithiane-2-propanamine, as well as their acid addition salts, in particular for use in eliminating cytostatic resistance in tumor treatment and chloroquine resistance in malaria.

REFERENCES:
patent: 4003914 (1977-01-01), Ramuz
patent: 4073797 (1978-02-01), Ramuz
patent: 4127588 (1978-11-01), Ramuz
Tsuruo et al., Cancer Res. 41:1967-1972 (1981).
Ramuz et al., Eur. J. Med. Chem. 24:493-496 (1989).

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