Method of monitoring compliance with methadone treatment program

Chemistry: analytical and immunological testing – Nitrogen containing – Amine and quaternary ammonium

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436816, 436901, G01N 3348

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active

061241369

ABSTRACT:
A method of monitoring compliance of a patient that has been placed on a methadone maintenance program by determining plasma methadone concentration from urine methadone concentration. An unadulterated urine sample is obtained from the patient. The urine methadone concentration, pH, and specific gravity are measured. The plasma methadone concentration is calculated as a function of urine methadone concentration, specific gravity, and pH. The calculated plasma methadone concentration is compared with an expected value for the maintenance program prescribed.

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Balabanova et al. "Methadone Distribution in Blood, Cerebrospinal Fluid, Urine and Organ Tissue", EMBASE No: 92091431.
Nilsson et al. "Effects of Urinary pH on the Disposition of Methadone in Man", EMBASE No: 82171209.

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