Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1990-02-08
1991-02-12
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514885, A61K 31185
Patent
active
049924702
ABSTRACT:
.beta.-methyl-.beta.butyrate (HMB) has been found to be markedly more effective for activating the immune function of T lymphocytes of mammals than .alpha.-ketoisocaproate (KIC). For activation of the T lymphocytes, .beta.-methyl-butyric acid or an edible water-soluble salt thereof is administered to the mammal by a route through which the HMB enters the blood of the mammal. The amount administered is sufficient for effective enhancement of the blastogenesis of their T lymphocytes. The method is adapted for use with domestic mammals, including particularly cattle, sheep, and swine. HMB can also be used with humans as an immune system stimulant.
REFERENCES:
Chem. Abst. 108:74242a (1988), Nissen.
Chem. Abst. 104:49689m (1986), Meerson et al.
Chem. Abst., 106:78426v (1987), Kryzhanovskii.
Kuhlman, Roth and Nissen, Abstract 236, FASEB Journal, vol. 3, No. 3, dated Feb. 9, 1989 (published Feb. 10, 1989--see attached letter.)
Fay Zohreh A.
Iowa State University & Research Foundation, Inc.
Robinson Douglas W.
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