2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use

Details 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines use

1993-06-10

1994-04-12

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544298, A61K 31505, C07D23902

Patent

active

053025970

ABSTRACT:
The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are now found to have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase providing treatment of conditions advantageously affected by such inhibition including inflammation, arthritis, pain, fever and the like. Thus, the present invention is also a pharmaceutical composition or method of manufacturing a pharmaceutical composition for the use of treating the noted conditions.

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