Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins

Details Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins

1977-04-04

1978-09-05

Thomas, Jr., James O.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

562430, 424309, 424319, C07C14375, A61K 3121, A61K 3119

Patent

active

041122364

ABSTRACT:
Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins are prepared by the two-stage alkylation of the anion of a lower alkyl sulfonamide, R.sup.1 SO.sub.2 NH.sub.2, using first a compound of the formula: ##STR1## and second, a compound of the formula: ##STR2## The compounds produced have renal vasodilatory activity when administered orally and are therefore useful for treating patients with renal impairment.

REFERENCES:
patent: 3991106 (1976-11-01), Cragoe

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