Method of introducing hydroxyl groups into artemisinin and its d

Details Method of introducing hydroxyl groups into artemisinin and its d Method of introducing hydroxyl groups into artemisinin and its d

1991-10-31

1992-12-15

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435125, 435254, 435911, 514450, 549348, C12P 1708, C12P 1706, C12R 1645

Patent

active

051716763

ABSTRACT:
The fungus Beauveria sulfurescens has been employed to introduce hydroxyl groups into artemisinin and derivatives of artemisinin, an antimalarial. Hydroxylated derivatives of artemisinin and derivatives of artemisinin produced thereby possess antimalarial activity, and can serve as intermediates in the synthesis of further derivatives useful in treating malaria.

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Lee et al. (1990) Pharmaceutical Research 7(2):199-203.
Chem Abst 14-127(1) Hufford et al. "Pharm Res (Phreeb)" v7 (9), pp. 923-927 (1990).
Biotech Abst. 87-03099 Marakby et al. "Pharm Res" (1986) 3,5, Suppl. 215.
BioTech Abs 91-14058 Hu et al. ASCRAL "Abs Pap Am Chem Soc" 1991 (202) Pt I BioTech 170.
BioTech Abs 91-12895 Hu et al. JCCCAT "J. Chem. Soc. Chem. Comm" (1991) 17 pp. 1176-1177.

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