Hydantoin derivatives as therapeutic agents

Details Hydantoin derivatives as therapeutic agents Hydantoin derivatives as therapeutic agents

1977-02-11

1978-09-26

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602955B, 424256, 424273R, 548308, C07D49110, C07D49510

Patent

active

041172302

ABSTRACT:
A series of spiro-hydantoin compounds has been prepared by condensing the appropriate carbonyl ring compound, such as the corresponding 1-indanone, 1-tetralone, 4-chromanone, thiochroman-4-one, 7,8-dihydroquinolin-5(6H)-one, 6,7-dihydropyrindin-5(5H)-one, thiondane-3-one-1,1-dioxide and 4-oxoisothiochroman-2,2-dioxide, respectively, with potassium cyanide and ammonium carbonate. The resulting hydantoin derivatives are found to be useful in preventing or alleviating chronic diabetic complications. Preferred member compounds include spiro-[imidazolidine-4,1'-indan]-2,5-dione, 6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6-chloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,7-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6,8-dichloro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione, 6'-fluoro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione and 6',7'-dichloro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione.

REFERENCES:
patent: 2683718 (1954-07-01), Dornfeld et al.
patent: 2716648 (1955-08-01), Jules et al.
patent: 3532744 (1970-10-01), Fletcher et al.
Arnold et al., Chem. Abst. 1963, vol. 58, cols. 3439-3440.
Boehme et al., Chem. Abst. 1974, vol. 80, No. 108305u.

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