Novel 5,6,7,8-tetrahydro-5-quinolines and their use as anti-infl

Details Novel 5,6,7,8-tetrahydro-5-quinolines and their use as anti-infl Novel 5,6,7,8-tetrahydro-5-quinolines and their use as anti-infl

1975-10-08

1978-09-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260283CN, 260283R, 260280CE, 260289H, 2602949, 260295F, 260295K, 260296B, 424263, C07D21516, A61K 3147, C07D21518, C07D21520

Patent

active

041171357

ABSTRACT:
Pyridine derivatives of the formula ##STR1## wherein R.sub.1 is an alkyl, aliphatic, a cycloalkyl, or a substituted or unsubstituted hydrocarbon aryl and the substituent is halogen, alkoxy or methylenedioxy; R.sub.2 is H or Cl; X is CN, 5-tetrazolyl, or COOH or a carboxylic acid derivative; Y is H, OH, OCOR.sub.7, NH.sub.2, NHCOR.sub.8, R.sub.9, COOH or COOR.sub.10 and R.sub.7, R.sub.8, R.sub.9 and R.sub.10 are alkyl groups of 1-10 carbon atoms; A is methylene or a carbon-to-carbon bond; and R.sub.3 and R.sub.4 are each H or alkyl groups of 1-4 carbon atoms, are useful as anti-inflammatory agents.

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patent: 3998831 (1976-12-01), Curran
patent: 4011225 (1977-03-01), Curran et al.
Juby et al.; J. Med. Chem., vol. 12, pp. 396-401 (1969).
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Buchanan et al., J. Med. Chem. vol. 12, pp. 1001-1006, (1969).
Morrison et al., Organic Chemistry 2nd Edition, pp. 589-591, (1969).
Seibert et al.; Chem. Abst. vol. 41: 2054a (1947).
Protiva et al.; Chem. Abst. vol. 45: 9522a (1951).
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