Method for treating acute alkali exposure with carbon dioxide

Details Method for treating acute alkali exposure with carbon dioxide Method for treating acute alkali exposure with carbon dioxide

1991-11-25

1993-11-16

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Carbon disulfide, monoxide, or dioxide

424DIG13, A61K 3300

Patent

active

052621804

ABSTRACT:
The present invention provides a method for combatting damage to a body tissue contacted to an alkali. The method comprising administering CO.sub.2 to the subject in an amount sufficient to produce an acidotic state in the tissue, the acidotic state serving to prevent alkali damage to the tissue. In a preferred embodiment of the invention, a subject is caused to inhale a mixture of 95%O.sub.2 and 5%CO.sub.2 for brief periods of time, followed by periods of breathing room air. The invention is particularly useful for treating alkaline injury of the esophagus caused by ingestion of alkaline material.

REFERENCES:
patent: 1599883 (1926-09-01), Gilchrist
patent: 3121663 (1964-02-01), Parker
patent: 3876773 (1975-04-01), Bracken
patent: 4608257 (1986-08-01), Teeter
patent: 4676774 (1987-06-01), Semm et al.
patent: 4678661 (1987-07-01), Gergely et al.
patent: 4735603 (1988-04-01), Goodson et al.
Cotzhauzen "Gleanings from the German Journals" Am J. Pharm, pp. 318, and 319 Jun. 1880.
Merck Manual "Respiratory Alkalosis", pp. 951-952, 1982.
The Merck Manual, 14th Ed., pp. 1877-1879 (1982).

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