Process for the purification of acarbose with polymers

Details Process for the purification of acarbose with polymers Process for the purification of acarbose with polymers

1986-05-29

1988-08-30

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 11, 536 187, 428402, C07H 106

Patent

active

047678500

ABSTRACT:
In the purification of acarbose by contacting an acarbose-containing solution with a cation exchanger to adsorb the acarbose, eluting the ion exchanger and collecting an eluate fraction enriched in purified acarbose, the improvement wherein the cation exchanger is a polymer obtained by polymerizing an aromatic compound possessing at least one vinyl group and at least one hydrophilic monomer in the presence of a solvent for the monomer which is a precipitant for the crosslinked polymer formed, isolating the resistant polymer, and sulphonating the polymer in the presence of a swelling agent for the polymer. The invention gives sharp separation and other processing advantages.

REFERENCES:
patent: 3864166 (1975-02-01), Barker et al.

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