Ornithine derivatives and their use as methotrexate-resistant ce

Details Ornithine derivatives and their use as methotrexate-resistant ce Ornithine derivatives and their use as methotrexate-resistant ce

1987-11-04

1988-08-30

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544260, A61K 31495, C07D47508

Patent

active

047677619

ABSTRACT:
Compounds having the structure ##STR1## in which R is --CO--Ar--COOR.sub.1 where R.sub.1 is hydrogen or lower alkyl, and pharmaceutical compositions containing the same exhibiting high growth inhibitory activity against methotrexate resistant cells.

REFERENCES:
patent: 4369319 (1983-01-01), DeGraw, Jr. et al.
Rosowsky et al., J. Med. Chem. vol. 29, pp. 655-660 (1986) and 1703-1709 (1986).
Bodanszky et al., J.A.C.S., vol. 86, pp. 4452-4459 (1964).
Mosmann, J. of Immunol. Methods, vol. 65, pp. 55-63 (1983).

Affiliated with

Also associated with

Rating

Ornithine derivatives and their use as methotrexate-resistant ce does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ornithine derivatives and their use as methotrexate-resistant ce, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ornithine derivatives and their use as methotrexate-resistant ce will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2088414