Drug – bio-affecting and body treating compositions – Chewing gum type
Patent
1986-12-16
1988-08-30
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Chewing gum type
424 49, 514 59, 536112, A61K 968, A61K 716, A61K 3173, A61K 31735
Patent
active
047676140
ABSTRACT:
The compounds of the present invention are linear and branched dextrans having a plurality of their glucose units modified at the 3-position ring carbon with groups selected from the class consisting of keto, amino, halo, benzyl, alkyl, sulfonyl, carboxyl and hydrogen. The modified dextrans reduce and/or modify activity of glucosyltransferase enzymes (GTF) which are produced by oral strains of Streptococcus mutans bacteria. GTF enzymes mediate oral biosynthesis of plaque-forming glucose polymers (glucans) from ingested sucrose. Therefore, the dextrans of the present invention, which reduce and/or modify activity of GTF enzymes, are useful in reducing the formation of dental plaque. The present invention is further directed to a dental health method comprising the step of contacting the oral cavity with linear or branched dextran compounds having a plurality of their glucose units modified at the 3-position carbon with a group such as keto, amino, halo, benzyl, alkyl, sulfonyl, carboxyl or hydrogen.
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Chludzinski Andrew M.
Janic Milan D.
Scarpa Ioannis S.
Griffin Ronald W.
Stone Jacqueline M.
Wm. Wrigley Jr. Company
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