N-(Substituted carbonylmethyl) isatoic anhydrides

Details N-(Substituted carbonylmethyl) isatoic anhydrides N-(Substituted carbonylmethyl) isatoic anhydrides

1975-01-03

1977-04-26

Meyers, Albert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424857, 42424858, C07D26500, C07D27300, C07D29500, A01N 900

Patent

active

040200620

ABSTRACT:
Isatoic anhydrides of the formula: ##STR1## wherein R is alkyl, phenyl or phenalkyl and R.sub.1 and R.sub.2 are hydrogen, halo, alkyl, alkoxy or together methylenedioxy are intermediates reactable with an acyclic 5-methyl-thiopseudourea and acetonitrile to pharmaceutical agents, for example, analgetic and hypotensive agents, of the formula: ##STR2## wherein R, R.sub.1 and R.sub.2 are as defined and R.sup.o is hydrogen, alkyl, .omega.-alkenyl or phenyl.

REFERENCES:
patent: 2910488 (1959-10-01), Novello
patent: 3351659 (1967-11-01), Santilli et al.
patent: 3383415 (1968-05-01), Carabateas
patent: 3725321 (1973-04-01), Wirth et al.
patent: 3729473 (1973-04-01), Boshagen et al.
patent: 3887550 (1975-06-01), Beckwith
J. of Biol. Chem. 244(II), 3009-3018, (1969)--Jovin et al.--Enzymatic Synthesis of Deoxyribonucleic Acid.

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