Piperidine opioid antagonists

Details Piperidine opioid antagonists Piperidine opioid antagonists

1989-12-11

1991-02-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

049924508

ABSTRACT:
This invention provides trans-3,4 1-substituted-3-substituted-4-methyl-4-(3-substituted phenyl)piperidines as opioid antagonists capable of blocking the mu or kappa receptors in the brain.

REFERENCES:
patent: 3991199 (1976-11-01), Berger
patent: 4141980 (1979-02-01), Berger
patent: 4191771 (1980-03-01), Zimmerman
patent: 4581456 (1986-04-01), Barnett
Leander et al., European Journal of Pharmacology 81, 185-192.
Leander et al., Drug Development Research 4: 421-427 (1984).
Baile et al., Physiology & Behavior, vol. 26, 1019-1023 (1981).
Zimmerman et al., Nature, vol. 275, Sep. 28, 1978, pp. 332-334.
Leander, The Journal of Pharmacology and Experimental Therapeutics, vol. 224, No. 1, 89-94 (1983).

Affiliated with

Also associated with

Rating

Piperidine opioid antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Piperidine opioid antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Piperidine opioid antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-20841