Process for the preparation of ranitidine

Details Process for the preparation of ranitidine Process for the preparation of ranitidine

1982-12-09

1985-02-05

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30752

Patent

active

044979614

ABSTRACT:
The invention relates to a process for the preparation of ranitidine of formula (I) ##STR1## which comprises reacting a thiol of formula (II) ##STR2## with an alkylating agent of formula (III) ##STR3## where L is a leaving group, preferably halogen.

REFERENCES:
patent: 4128658 (1978-12-01), Price et al.
patent: 4276421 (1981-06-01), Baudet
Patai, The Chemistry of the Thiol Group, Part 2, John Wiley & Sons, New York (1974), pp. 806-817, 834-839.
Toso et al., Gazz Chin, vol. 109 (1979), pp. 529-533.

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