Antibiotic purification process

Details Antibiotic purification process Antibiotic purification process

1975-02-10

1976-09-28

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D50124, C07D50160

Patent

active

039831086

ABSTRACT:
Cephamycin C is concentrated and purified by subjecting a fermentation broth which contains Cephamycin C to the following sequence of steps: filtration at acidic pH, adsorption of filtrate on activated carbon, removing the adsorbed antibiotic by contacting the carbon with a mixture of water and a polar organic solvent, contacting the eluate with an anion exchange resin, and eluting the resin with a salt solution at a pH of from about 5.5 to about 10.

REFERENCES:
patent: 3467654 (1969-09-01), McCormick
patent: 3709880 (1973-01-01), Goegelman et al.
patent: 3733320 (1973-05-01), Pines et al.

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