Imidazole derivatives in the treatment of pain

Details Imidazole derivatives in the treatment of pain Imidazole derivatives in the treatment of pain

1974-04-18

1976-02-24

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260250R, 2602948R, 2602948G, 260295S, 260296R, 260297R, 424250, 424266, A61K 2700

Patent

active

039404862

ABSTRACT:
Compounds of the formula ##SPC1##
Wherein R.sub.1 represents lower alkyl, cycloalkyl or phenyl which is optionally substituted by halogen, lower alkyl or lower alkoxy, and one of the groups R.sub.2 and R.sub.3 represents phenyl which is optionally substituted by halogen, lower alkyl, hydroxy, lower alkoxy, lower alkylthio or lower alkylsulphonyl, and the other represents a 6-membered heteroaromatic radical containing 1 or 2 ring nitrogen atoms, their N-oxides and salts, with anti-inflammatory, antinociceptive and antipyretic activity, they are active ingredients of pharmaceutical compositions and can be used for the relief and removal of pain as well as for the treatment of rheumatic, arthritic and other inflammatory complaints; an illustrative example is 2-isopropyl-4(5)-(p-methoxyphenyl)-5(4)-3-pyridyl-imidazole.

REFERENCES:
patent: 3707475 (1972-12-01), Lombardino

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