Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-tr

Details Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-tr Process for the preparation of 9, 10-secocholesta-5,7,10 (19)-tr

1996-07-11

1997-12-16

Prior, Kimberly J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549554, 552653, C07C40100

Patent

active

056987145

ABSTRACT:
The invention recites a process for preparing 9,10-secocholesta-5,7,10(19)-trienes of formula (I) ##STR1## where R.sup.1 is hydrogen or a hydroxy-protecting group and R.sup.2 and R.sup.3 are independently hydrogen or OR.sup.1. The compounds are prepared from epoxides of the following formulas ##STR2## by reaction with a low-valent metal reagent formed by reducing a metal halide, M(z)X.sub.z, preferably WCl.sub.6.

REFERENCES:
Kluge, et al, Tetrahedron, 52 (8), pp. 2957-2976 (1996).
Curci, et al, J. Am. Chem. Soc., 116, pp. 8112-8115 (1994).

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