Preparation of alkylesters of 0,0-dialkyl-4-phosphono-2-methyl-2

Details Preparation of alkylesters of 0,0-dialkyl-4-phosphono-2-methyl-2 Preparation of alkylesters of 0,0-dialkyl-4-phosphono-2-methyl-2

1995-09-28

1998-02-10

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

560219, C07F 940, C07C 6965

Patent

active

057171289

ABSTRACT:
A process for the preparation of alkyl esters of 0,0-dialkyl-4-phosphono-2-methyl-2-butenoic acid containing a high percentage of E isomers, wherein the corresponding alkyl esters of 2-hydroxy-2-methyl-3-butenoic acid are caused to react with PBr.sub.3 or PCl.sub.3 at temperatures ranging from 0.degree. to 80.degree. C. in the absence of pyridine and, if desired, the resulting mixture comprising predominantly alkyl esters of 4-halo-2-methyl-2-butenoic acid is caused to react with trialkyl esters of phosphorous acid at temperatures ranging from 70.degree. to 140.degree. C. The end products are desirable C.sub.5 building blocks for polyene syntheses or preceding stages.

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Houben-Weyl, vol. 5/3, p. 898 ff (1952).
Helv. Chim. Acta 1966, pp. 369-390.

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