Process for preparing indole derivatives containing a 1,2,4-tria

Details Process for preparing indole derivatives containing a 1,2,4-tria Process for preparing indole derivatives containing a 1,2,4-tria

1996-05-20

1998-02-10

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24912

Patent

active

057171041

ABSTRACT:
A process for preparing tryptamine derivatives and related compounds having a 1,2,4-triazol-1-yl moiety within the molecule comprises reacting 4-amino-1,2,4-triazol with a nitrobenzene derivative containing a readily displaceable group; deaminating the aminotriazolium salt thereby obtained by treatment with nitrous acid followed by neutralisation; reducing the triazolyl-ni-trobenzene derivative thereby obtained by transfer hydrogenation; treating the triazolyl-aniline derivative thereby obtained with nitrous acid and then with an alkali metal sulphate, followed by acidification; and subsequently reacting the triazolyl-hydrazine derivative thereby obtained in situ with a suitable carbonyl compound, to obtain the required triazolyl-indole derivative.

REFERENCES:
Cram a Hammond, "Organic Chemistry"; 2nd Ed, pp. 565-567, (1964).
Eur. J. Med. Chem., vol. 24 (1989) 537-540, "Synthesis and Antimycotic Activty of New (1H-1,2,4-triazol-1-yl-methyl) benezeneamine derivatives" by M. Scalzo et al.

Affiliated with

Also associated with

Rating

Process for preparing indole derivatives containing a 1,2,4-tria does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing indole derivatives containing a 1,2,4-tria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing indole derivatives containing a 1,2,4-tria will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2078433