Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyr

Details Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyr Process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyr

1997-03-25

1998-02-10

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23952

Patent

active

057170967

ABSTRACT:
A novel process for the preparation of a 2-alkoxy-6-(trifluoromethyl)pyrimidin-4-ol of the general formula: ##STR1## in which R is a C.sub.1 -C.sub.8 -alkyl group. In the process, cyanamide is reacted with the appropriate alcohol in the presence of hydrogen chloride to give the corresponding alkoxyisourea hydrochloride, which is then converted with ethyl trifluoroacetoacetate in the presence of an alkali metal hydroxide, which is in water, to the end product of the formula I.

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patent: 3966730 (1976-06-01), Hofer et al.
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patent: 5463055 (1995-10-01), Hintermaier et al.
Felczak et al., J. Med. Chem., vol. 39, No. 8, (Apr. 12, 1996), pp. 1720 to 1728.
Botta et al., Tetrahedron, 84, vol. 40, (17), pp. 3313 to 3320 (1984).
Lutz et al., J. Heterocycl. Chem., vol. 9, No. 3, (Jun. 1972), pp. 513 to 522.

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