Process and intermediates for preparing compounds having a disub

Details Process and intermediates for preparing compounds having a disub Process and intermediates for preparing compounds having a disub

1991-07-15

1998-02-10

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544333, 544335, 544362, 544363, 544376, 546152, 546174, 546425, 5469 23, 5469398, 5469405, C07D31104

Patent

active

057170940

ABSTRACT:
A process is disclosed for the preparation of disubstituted acetylene derivatives having retinoic acid like biological activity, wherein 6-ethynyl-chroman, 6-ethynyl-thio chroman and 6-ethynyl-1,2,3,4-tetrahydroquinoline derivatives of the formula shown below are reacted in the presence catalysts with halogenated phenyl or heteroaryl derivatives of to provide the disubstituted acetylenes.

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