Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-05-30
1998-02-10
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
057169780
ABSTRACT:
A method for treating circadian rhythm disorders is described. The method involves the administration of melatonin from about 6 hours to about 19 hours prior to when the normal sleep phase should begin, depending on whether a phase advance shift in circadian rhythms or a phase delay shift is desired. This is typically from about 4 hours to about 17 hours prior to the time of endogenous melatonin onset.
REFERENCES:
patent: 4600723 (1986-07-01), Short et al.
patent: 4665086 (1987-05-01), Short et al.
patent: 4687763 (1987-08-01), Wurtmann
patent: 5163426 (1992-11-01), Czeisler et al.
patent: 5167228 (1992-12-01), Czeisler et al.
patent: 5176133 (1993-01-01), Czeisler et al.
Deguchi, T., J. of Neural Transmission, Suppl. 13, 115-128 (1978).
Blood et al., 1993, "Serengeti.RTM. vermilion sunglasses inhbit the suppressant effect of bright light on melatonin secretion", Sleep Res. 22: 394 (Abst).
Claustrat et al., 1992, "Melatonin and jet-lag: confirmatory result using a simplified protocol", Biol. Psychiatry 32: 705-711.
Lewy et al., 1992, "Melatonin shifts human circadian rhythms according to a phase-response curve", Chronobiol. Int'l. 9: 380-392.
Nickelsen et al., 1991, "The effect of 6-, 9-and 11-hour time shifts on circadian rhythms: adaptation of sleep parameters and hormonal patterns following the intake of melatonin or placebo", Adv. Pineal Res. 5: 303-306.
Armstrong, 1991, "Treatment of sleep disorders by melatonin administration", Adv. in Pineal Res. 6: 263-274.
Samel et al., 1991, "Influence of melatonin treatment on human circadian rhythmicity before and after simulated 9-hr time shift", J. Biol. Rhythms 6: 235-248.
Wirz-Justice et al., 1990, "Morning or night-time melatonin is ineffective in seasonal affective disorder", J. Psychiatr. Res. 24: 129-137.
Skene et al., 1989, "Melatonin, jet-lag and the sleep-wake cycle", Sleep '88 (J. Horne, ed.), pp. 39-41.
Petrie et al., 1989, "Effect of melatonin on jet lag after long hauls", Br. Med. J. 298 705-707.
Armstrong, 1989, "Melatonin and circadian control in mammals", Experientia 45: 932-938.
Rosenthal et al., 1988, "Atenolol in seasonal affective disorder: A test of the melatonin hypothesis", Amer. J. Psychiatry 145: 52-56.
Mallo et al., 1988, "Effects of a four-day nocturnal melatonin treatment on the 24 h plasma melatonin, cortisol and prolactin profiles in humans", Acta Endocrinol. 119: 474-480.
Parry et al., 1987, "Treatment of a Patient with Seasonal Premenstrual Syndrome," Amer. J. Psychiatry 144: 762-766.
Arendt et al., 1987, "Some effects of jet-lag and their alleviation by melatonin", Ergonomics 30: 1379-1393.
Underwood, 1986, "Circadian Rhythms in Lizards: Phase Response Curve for Melatonin", J. Pineal Res. 3: 187-196.
Arendt et al., 1985, "Some effects of melatonin and the control of its secretion in humans", CIBA Found. Symp. 117: 266-283.
Arendt et al., 1984, "The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: A preliminary study", Neurosci. Lett. 45: 317-325.
Lewy et al., 1983, "Neuropsychobiology of Circadian and Seasonal Rhtyhms: Light as a `Drug`?," Psychopharmacol. Bull. 19: 523-4.
Gwinner, 1978, "The effects of pinealectomy on circadian locomotor activity rhythms in European starlings, Sturnus vulgaris", J. Comp. Physiol. 126: 123-129.
Lewy Alfred J.
Sack Robert L.
Spivack Phyllis G.
State of Oregon
LandOfFree
Methods of treating circadian rhythm disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods of treating circadian rhythm disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of treating circadian rhythm disorders will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2077691