Protein kinase C modulators. H.

Details Protein kinase C modulators. H. Protein kinase C modulators. H.

1995-06-07

1998-02-10

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514415, 514483, 514547, A61K 31445

Patent

active

057169683

ABSTRACT:
Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the diaminobenzyl alcohol- and diacylglycerol-classes.

REFERENCES:
patent: 4376821 (1983-03-01), Braude
patent: 4376822 (1983-03-01), Braude
patent: 4401756 (1983-08-01), Gillis
patent: 4460685 (1984-07-01), Vilcek et al.
patent: 4560774 (1985-12-01), Pettit et al.
patent: 4716179 (1987-12-01), Hecker et al.
Jeffrey, A. and Liskamp, R., "Computer-Assisted Molecular Modeling of Tumor Promoters: Rationale for the Activity of Phorbol Esters, Teleocidin B, and Aplysiatoxin," Proc. Natl. Acad. Sci. USA 83: 241-245 (Jan. 1986).
Sugimura, T., "Potent Tumor Promoters Other Than Phorbol Ester and Their Significance," Gann 73(4): 499-507 (Aug. 1982).
Nishizuka, Y., "The Role of Protein Kinase C in Cell Surface Signal Transduction and Tumour Promotion," Nature 308: 693-698 (Apr. 19, 1984).
Ganong, B., et al., "Specificity and Mechanism of Protein Kinase C Activation by sn-1,2-diacylglycerols," Proc. Natl. Acad. Sci. USA 83: 1184-1188 (Mar. 1986).
Schmidt, R. and Hecker, E., "Simple Phorbol Esters as Inhibitors of Tumor Promotion by TPA in Mouse Skin," Carcinogenesis 7: 57-63 (1982).
Wender, P. et al., "Analysis of the Phorbol Ester Pharmacophore on Protein Kinase C as a Guide to the Rational design of New Classes of Analogs," Proc. Natl. Acad. Sci. USA 83: 4214-4218 (Jun. 1986).

Affiliated with

Also associated with

Rating

Protein kinase C modulators. H. does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein kinase C modulators. H., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein kinase C modulators. H. will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2077636