Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-06
1998-02-10
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3144
Patent
active
057169624
ABSTRACT:
A process for the long term modification and regulation of lipid and carbohydrate metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia or hyperglycemia, or both (these are the hallmarks of noninsulin dependent, or Type II diabetes)--by administration (i.e., by oral, sublingual or parenternal administration) to a vertebrate, animal or human, of a dopamine agonist, e.g., bromocriptine. Administration of the bromocriptine is made over a limited period at a time of day dependent on the normal circadian rhythm of insulin resistant and insulin sensitive members of a similar species. Insulin resistance, and hyperinsulinemia and hyperglycemia, or both, can be controlled in humans on a long term basis by such treatment inasmuch as the short term daily administration resets hormonal timing in the neural centers of the brain to produce long term effects.
REFERENCES:
patent: 3074847 (1963-01-01), Bigsby et al.
patent: 4239763 (1980-12-01), Milvec et al.
patent: 4659715 (1987-04-01), Meier et al.
patent: 4749709 (1988-06-01), Meier et al.
patent: 4783469 (1988-11-01), Meier et al.
patent: 5006526 (1991-04-01), Meier et al.
patent: 5468755 (1995-11-01), Cincotta et al.
Burns et al., Chronopharmacology and Chronotherapeutics, Int'l Symp. on Chronopharm. and Chronother., Florida A&M University, 1988.
Harel et al., Proc. La. Acad. of Sci., 38:125, 1975.
Joseph et al., Proc. Soc. Exp. Biol. Med., 146: 1150-1155, 1974.
Komorowski et al., Aliment. Nutr. Metab., 1(4): 293, 1980.
Larsson et al., Lakartidningen (Sweden), 82(50): 4425, 1985.
Martin et al., "Hormonal Control of Orientation in the White-Throated Sparrow, Zonatrichia albicollis" Chronobiology, pp. 641-646, 1974.
Martin et al., Proc. La Acad. of Sci., 38: 127, 1975.
Martin et al., Am. Zoologist, 18(3): 572, 1978.
Martin, D., "Hormonal Regulation of Migratory Orientation in the White-Throated Sparrow, Zonatrichia albicollis." Diss. LSU, 1974.
Martin, D., "Factors Influencing the Circadian Rhythm of Locomotor Activity in thge Anabatoid Fish, Trichogaster trichopterus sumatranus." Thesis. Sam Houston State College, 1969.
Meier et al., Experientia, 48:248-253, 1992.
Meier et al., Physiol. Zool., 4(1): 95-103, 1968.
Southern et al., J. Anim. Sci., 68: 931-936, 1990.
Barnett, Post Graduate Medical J. 56:11-14, 1980.
Bartness et al., J. Exp. Zoology 244:437-454, 1987.
Berle, Acta endocr. Suppl. 173, Abstract No. 104, 1973.
Cassar, J. et al. "Bromocriptine Treatment of Acromegaly," Metabolism 26: 539-546 (1977).
Cincotta et al., J. Endocrinol. 106: 177-181, 1985.
Cincotta et al. J. Endocrinol. 106: 173-176, 1985.
Cincotta et al., Life Sciences 45:2247-2254, 1989.
Cincotta, J. Endocrinol. 103: 141-146, 1984.
Cincotta et al., J. Endocrinol. 120:385-391, 1989.
Cincotta et al., Ann Nutr Metab 33:305-314, 1989.
Cincotta et al., Experientia 43:416-417, 1987.
Cincotta et al., Horm Metabol Res 21:64-68, 1989.
Dolocek, R. et al. "Bromocriptine and glucose tolerance in acromegalics," Pharmatherapeutica 3: 100-106 (1982).
Eisemann et al., J. of Animal Sci. 59(1)95-104, 1984.
Eisemann et al., J. of Animal Sci. 59(1)86-94, 1984.
Emata et al., J. Exp. Zoology 233:29-34, 1985.
Eskildsen, P.C. et al. "Long-Term Treatment of Acromegaly with Bromocriptine," Acta Endocr. 87: 687-700 (1978).
Horseman et al., General and Comparative Endocrinology 38:269-274, 1979.
Horseman et al., J. Endocr. 82:367-372, 1979.
Joseph et al., J. Exp. Zool. 178(1):59-62, 1971.
Lee et al., J. of Exp. Zool. 166(3):307-316, 1967.
Lobato et al. Mol. and Cell Biochem. 67:19-23, 1985.
Martin et al., Neuroendocrinology 52: 9-14, 1990.
Martin et al., The Condor 75: 369-374, 1973.
Meier et al., General and Comparative Endocrinology Suppl. 3:499-508, 1972.
Meier et al., Amer. Scientist 61(2) 184-187, 1973.
Meier et al., Biology of Reproduction 8:400-410, 1973.
Meier et al., General and Comparative Endocrinology 26:253-258, 1975.
Meier et al., Proc. Soc. Exp. Biol. and Med. 133(4):1113-16, 1970.
Meier et al., Science 173: 1240-42, 1971.
Meier et al., Gen. & Comp. Endocrin. 17:311-318, 1971.
Meier et al., Proc. Soc. for Exp. Bio. & Med. 137:408-415, 1971.
Meier et al., Gen & Comp. Endocrin. 8(1):110-114, 1967.
Meier et al., Transactions of the American Fisheries Society 113:422-431, 1984.
Meier et al., Current Ornithology 2:303-343, 1984.
Meier et al., Circadian hormone basis for seasonal conditions in the gulf killifish Fundulus grandi in Comparative Endocrinology, pp. 141-144. Galliard et al. (eds), Elsevier/North Holland Biomedical Press, Amsterdam (1978).
Meier et al., Amer. Zool. 16:649-659, 1976.
Meier et al., Amer. J. Physiology 23(2):E193-E196, 1977.
Miller et al., J. Interdiscipl. Cycle Res. 14(1):75-84, 1983.
Miller et al., J. Interdiscipl. Cycle Res. 14(2):85-94, 1982.
Moore et al., Biology of Reproduction 36:47-58, 1987.
Ottenweller et al., Life Sciences 28:1033-1040, 1981.
Spieler et al., Life Sciences 22:255-258, 1977.
Steinbeck, K. and J.R. Turtle, "Treatment of Acromegalywith Bromocryptine," Aust. N.Z. J. Med. 9: 217-224 (1979).
Thomas et al., Sem. des Hosp. de Paris, 53(34-35):1857-1862, 1977.
Wass, J.A.H. et al. "An Assessment of Glucose Intolerance In Acromegaly and Its Response to Medical Treatment," Clin. Endocr. 12: 53-59 (1980).
Wilson, Chrono. Bio. Int. 6:113-121, 1989.
Cincotta Anthony H.
Meier Albert H.
The Board of Supervisors of Louisiana State University and Agric
Weddington Kevin E.
LandOfFree
Process for therapeutically modifying and resetting prolactin rh does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for therapeutically modifying and resetting prolactin rh, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for therapeutically modifying and resetting prolactin rh will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2077595