Process for the long term reduction of body fat stores, insulin

Details Process for the long term reduction of body fat stores, insulin Process for the long term reduction of body fat stores, insulin

1995-05-26

1998-02-10

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 4, C07K 1464, C07K 900, A61K 3800

Patent

active

057169322

ABSTRACT:
A process for the long term modification and regulation of lipid metabolism--generally to reduce obesity, insulin resistance, and hyperinsulinemia (the three hallmarks of Type II diabetes)--by injections into the bloodstream of a vertebrate, animal or human, of prolactin, or both prolactin and a glucocorticosteroid. The injections are made over a limited period at a time of day dependent on the normal circadian rhythm of fat and lean members of a similar species. Decreases (or increases) in body fat deposits result by treatment of an obese species (lean species) on a daily timed sequence based on circadian rhythms of the peak prolactin, or peak prolactin and peak glucocorticosteroid, blood level established for lean members (or obese members) of a similar species. Insulin resistance, and hyperinsulinemia can also be controlled in humans on a long term basis by treatment corresponding to that of the treatment for obesity. The short term daily injections reset hormonal timing in the neural centers of the brain to produce long term effects.

REFERENCES:
patent: 5344832 (1994-09-01), Cincotta et al.
patent: 5496803 (1996-03-01), Meier et al.
Van Cauter, E., "Diurnal and Ultradian Rhythms in Human Endocrine Functio A Minireview, Hormone Research, vol. 34, pp. 45-53 (1990).

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