Transdermal therapeutic system

Details Transdermal therapeutic system Transdermal therapeutic system

1993-01-19

1994-08-09

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424449, A61F 1302

Patent

active

RE0346926

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND AND SUMMARY OF THE INVENTION

The invention relates to a transdermal therapeutic system for the administration of active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control device controlling the delivery of the active substance through the system and a [contact] pressure sensitive adhesive fixing means for the therapeutic system to the skin, and to the use thereof.
Such transdermal systems with several active substances depots are e.g. known from P 36 29 404.0, in which one or more isolated active substance depots, which are not interconnected, are arranged in an active substance distribution matrix.
This known arrangement is particularly preferred for solid or very viscous materials, the highly concentrated active substance permeating into the active substance distribution matrix and from there flows onto the optionally [contact] pressure sensitive adhesive control membrane.
In the case of flowable active substances or active substance formulations, the active substance is frequently received in bag-like recesses of a matrix or in a bag formed by a controlling membrane or a film. When the active substance reservoir is exhausted, there is a rapid decrease in the internal pressure and of the migration speed of the active substance, too. Another disadvantage of systems with large bag-like units with a fluid active substance formulation is that they are sensitive to pressure and on the system being loaded by pressure, the complete active substance passes uncontrollably out of a burst bag into the active substance distribution matrix and the delivery of the active substance to skin then no longer takes place in controlled form. This is particularly undesired if it is a highly effective active substance, whose overdosing leads to risks.
Another disadvantage of the known systems is that they cannot be subdivided, e.g. for children and adults requiring less active substance different sizes have to be kept in stock.
Finally, in the case of a plaster with a larger liquid reservoir, as a result of gravity action a non-uniform distribution of the liquid occurs, which significantly impairs the uniformity of active substance delivery.
The problem of the present invention is therefore to avoid the aforementioned disadvantages of the prior art and to provide a novel transdermal therapeutic system, which permits more reliable handling, particularly of liquid active substances or active substance formulations.
According to the invention this problem is solved by a transdermal therapeutic system, which is characterized in that the active substance depot is a multichamber system, in which discrete chambers have one or more active substances.
A multichamber system is advantageous, because the distribution of the active substance is better and possibly the cutting off or separating of part of the transdermal therapeutic system does not lead to the flowing or dropping out of the complete active substance formulation. Furthermore, flowable active substance formulations can only move to a limited extent under the action of gravity or pressure, so that even under the influence of gravity a relatively uniform distribution of an active substance-containing liquid can be obtained. If as a result of pressure loading an active substance chamber bursts, the remaining chambers remain undamaged, so that the function of the system is to a certain extent maintained, which is a precautionary measure reducing overdosing risks in the case of highly effective liquid active substances.
An advantageous further development of the inventive concept consists of the individual chambers being at least partly interconnected by channels in such a way that a flow of the chamber content for pressure compensation purposes is possible.
It can be advantageous for the connecting channels between the chambers to have an internal diameter such that they permit the through flow of the active substance fluid only when pressure is applied. This embodiment avoids the bursting

REFERENCES:
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4822617 (1989-04-01), Panoz

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