Pyridazine carboxylic acids and esters

Details Pyridazine carboxylic acids and esters Pyridazine carboxylic acids and esters

1990-02-13

1991-02-12

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544239, A61K 3150, C07D23714

Patent

active

049924397

ABSTRACT:
Heterocyclic acids andesters useful as inhibitors of mammalian blood platelet aggregation characterized by Formula I or II are disclosed. ##STR1## Formula I compounds are those wherein n is 6-9, R is hydrogen, lower alkyl or an alkali metal ion, and HET.sub.1 is the heterocyclic radical 1,6-dihydro-6-oxo-3,4-diphenyl-1-pyridazinyl.
Formula II compounds are those wherein R.sub.1 is hydrogen, lower alkyl or an alkali metal ion, and the radical --OCH.sub.2 CO.sub.2 R is attached in the 3 or 4 ring position; and HET.sub.2 is the heterocyclic radical 1,6-dihydro-6-oxo-3,4-diphenyl-1-pyridazinyl.

REFERENCES:
patent: 2712542 (1955-07-01), King et al.
patent: 3622576 (1971-11-01), Baetz
patent: 4162317 (1979-07-01), Houlihan
patent: 4238490 (1980-12-01), Powers et al.
patent: 4545810 (1985-10-01), Pyne et al.

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