Integrated nucleic acid analysis system for MALDI-TOF MS

Details Integrated nucleic acid analysis system for MALDI-TOF MS Integrated nucleic acid analysis system for MALDI-TOF MS

1995-11-01

1998-02-10

Beisner, William H.

Chemistry: molecular biology and microbiology

Apparatus

Including condition or time responsive control means

4352872, 4352879, 4352884, 250288, 422 681, C12M 138, C12M 140

Patent

active

057168253

ABSTRACT:
An integrated nucleic acid sample analysis system for matrix-assisted laser-desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) is described. The integrated system comprises a miniaturized sample preparation compartment interfaced directly with a MALDI-TOF ionization surface for amplifying and/or otherwise chemically manipulating an oligonucleotide analyte and presenting the analyte to a MALDI ionization surface for mass spectrometry analysis. The miniaturized integrated sample handling system disclosed herein finds application in the amplification and analysis of DNA samples for genetic diagnosis and other uses.

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