Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4

Details Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4 Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4

1986-05-30

1987-07-21

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514423, 546256, 546275, 548517, 548537, A61K 3140, A61K 3135, C07D207327

Patent

active

046818936

ABSTRACT:
Certain trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
patent: 4198425 (1980-04-01), Mitsui et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mitsui et al.
patent: 4375475 (1983-03-01), Willard et al.
Singer, et al.; Proc. Soc. Exper. Biol. Med.; vol. 102, pp. 370-373, (1959).
Hulcher; Arch. Biochem. Biophys., vol. 146, pp. 422-427, (1971).
Brown, et al.; New England Jour. of Med., vol. 305, No. 9, pp. 515-517, (1981).
Brown, et al.; J. Chem. Soc. Perkin I, (1976), pp. 1165-1170.
Journal of the Americas Medical Assoc.; (1984), vol. 251, pp. 351-364, 365-374.

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